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Tipepidine hydrochloride

CAS No. 1449686-84-3

Tipepidine hydrochloride( —— )

Catalog No. M23615 CAS No. 1449686-84-3

Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Tipepidine hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
  • Description
    Tipepidine hydrochloride is a reversible inhibitor of dopamine (DA) D2 receptor-mediated GIRK currents (IDA(GIRK)) (IC50: 7.0 μM), with antidepressant-like effect.
  • In Vitro
    ——
  • In Vivo
    Animal Model:Male Wistar rats weighting 150-240 g (5-7 weeks old) Dosage:10, 20 and 40 mg/kg Administration:I.p.; 0.5, 5, 23 hours Result:Decreased the immobility time in the forced swimming test in ACTH-treated rats.
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Dopamine Receptor
  • Recptor
    D2
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1449686-84-3
  • Formula Weight
    311.89
  • Molecular Formula
    C15H18ClNS2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:41.67 mg/mL (133.60 mM; Need ultrasonic)
  • SMILES
    CN1C/C(CCC1)=C(C2=CC=CS2)\C3=CC=CS3.[H]Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Hamasaki R, et al. Tipepidine activates VTA dopamine neuron via inhibiting dopamine D? receptor-mediated inward rectifying K? current. Neuroscience. 2013 Nov 12;252:24-34.
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